Converging evidence for the pro-inflammatory role of p-glycoprotein in Th2 polarized chronic rhinosinusitis endotypes

Background T-helper 2 (Th2) inflammation is a hallmark of Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) and eosinophilic CRS (eCRS) although the pathogenesis is poorly understood. P-glycoprotein (P-gp) is an efflux pump which is expressed within sinonasal mucosa and is capable of regulating cytokine transport in both epithelial and T-cells. The purpose of this study was to synthesize multiple lines of evidence suggesting that P-gp may promote inflammation in Th2 polarized CRS endotypes.